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EC number: 285-349-9 | CAS number: 85085-18-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test carried out by GLP compliant laboratory to recognised validated methods by trained personnel
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Twenty rats (10 male, 10 female) were weighed and checked for health issues and acclimatised in a holding room prior to test initiation. They were housed in controlled humidity and temperature conditions. Ten rats were used for the substance exposure and 10 rats used for the control (clean air). Each rat was placed in individual compartments within a 0.13 cubic meter perspex chamber. Air flow was 25l/min (measured at the generator outlet)and the test material in powder form was introduced via this air stream for a period of 4 hours following a 12 minute equilibration period. The air was sampled 5 times during the 4 hour period and the particle size of the dust was also measured. After exposure the rats were returned to their cage and observed for signs of pharmacotoxic effects and mortality continuously after exposure and then at least twice daily for 14 days. After this time the rats were euthenased and subjected to gross necropsy.
- GLP compliance:
- yes
- Test type:
- fixed concentration procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Silicate(2-), hexafluoro-, disodium, reaction products with lithium magnesium sodium silicate
- EC Number:
- 285-349-9
- EC Name:
- Silicate(2-), hexafluoro-, disodium, reaction products with lithium magnesium sodium silicate
- Cas Number:
- 85085-18-3
- Molecular formula:
- Na0.7[Mg5.3Li0.7Si8O20(OH)0.0F4.0]
- IUPAC Name:
- Synthetic fluorohectorite
- Details on test material:
- The test material used for this inhalation study was Laponite B, supplied Dec 1982
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 240 min
- Concentrations:
- Durin the exposure, 5 samples were taken and the dust level ranged between 1.45 0 1.84 g/cubic meter. The average value was determined to be 1.66g/m3. This was the highest practical concentration that could be achieved with the apparatus used for the test. the PSD analysis showed that~47% of the dust was 5.5 microns or less and therefore in the respirable size region
- No. of animals per sex per dose:
- Exposed to the dust - 5 males, 5 females
Exposed to clean air (control) - 5 males, 5 females - Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 1 660 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No deaths were recorded following exposure of 10 rats to Laponite B dust at 1.66g/m3, which was the highest practical level attainable.
- Clinical signs:
- other: During the exposure: licking of the inside of the mouth, partial closure of eyes, abnormal breathing, lacrimation and lethargy in some animals. Signs were consistent with exposure to a mildly irritant dust. During the observation period: abnormal breathi
- Body weight:
- For the rats exposed to the dust there was a slight reduction in rate of group mean bodyweight on the day following exposure but after that, the rate of weight gain was similar to the control group.
- Gross pathology:
- The lung weight to bodyweight ratio were considered to be within normal limits.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- This test substance is not toxic to rats by inhalation under conditions of this test
- Executive summary:
The level of dust in the air as supplied by the methodology of the test could not be produced at a higher concentration than 1.66mg/l, this was the highest attainable level. At this level, there was no mortality or signs of toxicity exhibited by the exposed rats. As it was not possible to produce sufficiently high concentrations in the atmosphere to cause adverse effects, classification is not considered necessary. The maximum achieved concentration of 1.66 mg/l is used as part of the derivation of no effect levels
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