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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Although no guideline was followed the study contains sufficient experimental details to be evaluated satisfactory and reliable with restrictions.

Data source

Reference
Reference Type:
publication
Title:
Embryotoxic and teratogenic effects of CTAB, a cationic surfactant, in the mouse
Author:
B. Isomaa and K. Ekman
Year:
1975
Bibliographic source:
Fd Cosmet. Toxicol. Vol 13 pp 331-334

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
CTAB in aqueous solution was given in single ip injections to four groups each of eight mice. The median lethal dose and its standard error were estimated accorting to Miller & Tainter (1994)*.
*: Miller, L.C.. & Tainter, M.L. (1994). Estimation of the ED 50 and its error by means of logarithmic-probit graph paper. Proc. Soc. exp. Biol. Med. 57, 261.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified

Test animals

Species:
mouse
Strain:
NMRI
Sex:
female
Details on test animals and environmental conditions:
The animals were given commercial pellets and water ad. lib. and maintained in a 12 hour light-dark sequence under ambient conditions of 20± 1°C and 60 ± 5% humidity.

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: aqueous solution
Details on exposure:
Single ip injections
Doses:
no data
No. of animals per sex per dose:
Four groups each of eight mice
Control animals:
not specified

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
>= 85 - <= 127 mg/kg bw
Based on:
not specified
Mortality:
Death occured generally within 12 hr of administration. The animals that did not die recovered within 24 hr, although some delayed deaths did occur.
Clinical signs:
convulsions and respiratory depression

Applicant's summary and conclusion

Conclusions:
The acute ip LD50 for female mice was found to be 106±20 mg/kg bw.
Executive summary:

The acute ip LD50 for female mice was found to be 106±20 mg/kg bw.