Registration Dossier
Registration Dossier
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EC number: 200-311-3 | CAS number: 57-09-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Although no guideline was followed the study contains sufficient experimental details to be evaluated satisfactory and reliable with restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Embryotoxic and teratogenic effects of CTAB, a cationic surfactant, in the mouse
- Author:
- B. Isomaa and K. Ekman
- Year:
- 1 975
- Bibliographic source:
- Fd Cosmet. Toxicol. Vol 13 pp 331-334
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- CTAB in aqueous solution was given in single ip injections to four groups each of eight mice. The median lethal dose and its standard error were estimated accorting to Miller & Tainter (1994)*.
*: Miller, L.C.. & Tainter, M.L. (1994). Estimation of the ED 50 and its error by means of logarithmic-probit graph paper. Proc. Soc. exp. Biol. Med. 57, 261. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Cetyl trimethylammonium bromide (CTAB)
- IUPAC Name:
- Cetyl trimethylammonium bromide (CTAB)
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- The animals were given commercial pellets and water ad. lib. and maintained in a 12 hour light-dark sequence under ambient conditions of 20± 1°C and 60 ± 5% humidity.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: aqueous solution
- Details on exposure:
- Single ip injections
- Doses:
- no data
- No. of animals per sex per dose:
- Four groups each of eight mice
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 85 - <= 127 mg/kg bw
- Based on:
- not specified
- Mortality:
- Death occured generally within 12 hr of administration. The animals that did not die recovered within 24 hr, although some delayed deaths did occur.
- Clinical signs:
- convulsions and respiratory depression
Applicant's summary and conclusion
- Conclusions:
- The acute ip LD50 for female mice was found to be 106±20 mg/kg bw.
- Executive summary:
The acute ip LD50 for female mice was found to be 106±20 mg/kg bw.
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