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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Link to relevant study record(s)

Description of key information

In the key study, the acute toxicity to Daphnia magna of cetrimonium bromide was determined to be 26 microgram/L representing EC50 (48h).  The EC50(48h), 26 microgram/L was selected for the safety assessment. The key study is supported by three studies performed on Daphnia magna. EC50(48h) and EC50(24h) values reported are 16 to 26 microgram/L and 98 to 130 microgram/L, respectively.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
26 µg/L

Additional information

Short-term toxicity data were obtained from four different studies all performed on Daphnia magna. In the key study, the acute toxicity to Daphnia magna of cetrimonium bromide was determined to be 26 microgram/L representing EC50 (48h). Other studies supported the findings in the key study with EC50(48h) and EC50(24h) reported based on nominal concentrations as 16 to 26 microgram/L and 98 to 130 microgram/L, respectively. The EC50(48h) of 26 microgram/L is selected for the risk assessment, as it is the best described study, with no deviation from the OECD guideline. No data have been obtained for marine invertebrates.