Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

One study has examined the oral absorption, distribution and excretion of cetrimonium bromide.

One study has examined the percutaneous absorption of dodecyltrimethylammonium bromide in rats, in vivo

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
6
Absorption rate - dermal (%):
3

Additional information

From a toxicokinetic study with oral gavage administration of radioactive cetrimonium bromide to rats, an oral absorption rate of 3 - 9% (average 6%) has been estimated. Radioactivity in tissues declined rapidly and no bioccumulation in tissues could be expected.

From dermal exposure of rats to radioactive dodecyltrimethylammonium bromide, the percutaneous absorption of the applied radioactivity was 3.15% corresponding to 28.4 ug/cm2.