Registration Dossier
Registration Dossier
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EC number: 402-600-1 | CAS number: 765-12-8
Endpoint summary
Administrative data
Description of key information
Triethylenglycoldivinylether is non irritating to skin and eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation
The potential of Triethylenglycoldivinylether to cause acute dermal irritation or corrosion was assessed by a single topical application of 0.5 ml of the test substance to the intact skin of 3 white New Zealand rabbits for 4 hours under semi-occlusive dressing (GLP-guideline study; BASF 1997). The average score (24 to 72 hours) for irritation was calculated to be 0.2 for erythema and 0.0 for edema. The skin findings were reversible in all animals within 48 hours after removal of the patches; thus the study was terminated after 72 hours. Under the test conditions chosen and considering the described findings Triethylenglycoldivinylether does not give indication of an irritant property to the skin.
Eye irritation
The potential of Triethylenglycoldivinylether to cause damage to the eye was assessed in 3 white New Zealand rabbits, subjected to a single ocular application of 0.1 ml of the test substance (GLP-guideline study; BASF 1997). The average score (24 to 72 hours) for irritation was calculated to be 0.0 for corneal opacity, iris and chemosis and 0.3 for conjunctivae redness. The findings were reversible in all animals within 48 hours after application; thus the study was terminated after 72 hours. Under the test conditions chosen and considering the described findings, Triethylenglycoldivinylether does not give indication of an irritant property to the eye.
Justification for classification or non-classification
Classification is not warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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