Registration Dossier
Registration Dossier
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EC number: 402-600-1 | CAS number: 765-12-8
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50: > 2000 mg/kg bw
Acute dermal toxicity: LD50: > 4000 mg/kg bw
Acute inhalative toxicity: no data
Key value for chemical safety assessment
Additional information
Oral
For the investigation of the acute oral toxicity of Triethylenglycoldivinylether, three males and three females Wistar rats received a single oral dose of the test material preparation in olive oil at a dose level of 2000 mg/kg bw (GLP guideline study; BASF 1997). Signs of toxicity noted comprised impaired or poor general state, dyspnoea, apathy, abdominal position, staggering, ataxia, atonia, paresis and exsiccosis. The animals appeared normal 1 day after application. The expected body weight gain was observed in the course of the study. No mortality occurred. No abnormalities were noted at necropsy of animals sacrificed at the end of the study. Under the conditions of this study, the LD50 of Triethylenglycoldivinylether after oral application was found to be greater than 2000 mg/kg bw.
Dermal
For the determination of the acute dermal toxicity of Triethylenglycoldivinylether, the test material was applied undiluted at a dose level of 4000 mg/kg bw to the clipped epidermis (dorsal and dorsolateral parts of the trunk) of five male and five female rats and covered by a semi-occlusive dressing for 24 hours. Systemic signs of toxicity were not noted. A very slight erythema was observed in two male and two female animals 1 day after application. No abnormalities were noted at necropsy of animals sacrificed at the end of the study. No mortality occurred. Under the conditions of this study, the LD50 of Triethylenglycoldivinylether after dermal application was found to be greater than 4000 mg/kg bw.
Inhalative
The inhalative route is not a relevant route of exposure due to the low vapor pressure (0.0042 hPa) and use (no formation of an inhalable aerosol).
Justification for classification or non-classification
Classification for acute toxicity is not warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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