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EC number: 402-600-1 | CAS number: 765-12-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 44.1 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 6.8
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 12.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 24
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
Short term exposure worker (systemic effects)
It is not possible to derive a DNEL for acute effects based on the available data. The acute toxicity of Triethylenglycoldivinylether is low with respect to the oral and dermal routes of exposure. The inhalative route is not a relevant route of exposure due to the low vapour pressure (0.0042 hPa) and use (no formation of an inhalable aerosol).
Long term exposure worker (systemic effects)
Inhalatory and dermal
The DNELs for inhalatory and dermal long term exposure are derived from the NOAEL obtained in an oral repeated dose study (BASF 73R0162/03041). In this 2-generation reproduction toxicity study (comparable to the current OECD guideline 416) rats were exposed to 0, 100, 300, 1000 mg/kg bw/day for up to 20 weeks. Effects on liver and kidney weight (with corroborative histopathological findings) were observed in males and females at 1000 mg/kg bw/day. A dose level of 300 mg/kg bw/day is considered as NOAEL.
Long term worker (inhalation)
Description |
Value |
Remark |
Step 1) Relevant dose-descriptor |
NOAEL: 300 mg/kg bw (OECD 416; oral; rat) |
effects on liver and kidney weight |
Step 2) modification of the starting point |
|
|
|
1/0.38 |
route to route (8h exposure) |
|
50/100 |
absorption oral to inhal. |
|
6.7 m³/10 m³ |
to light work |
Step 3) Assessment factors |
|
|
Exposure duration |
2 |
subchronic to chronic |
Interspecies |
1 |
no interspecies extrapolation for inhal. |
Intraspecies |
3 |
worker |
DNEL |
Value |
|
For workers |
300 mg/kg x 0.5 x 0.67 / (0.38 x 2 x 1 x 3) = 44.1 mg/m³ |
Factor 6.8
Long term worker (dermal)
Description |
Value |
Remark |
Step 1) Relevant dose-descriptor |
NOAEL: 300 mg/kg bw (OECD 416; oral; rat) |
effects on liver and kidney weight |
Step 2) modification of the starting point |
|
|
|
1/1 |
route to route |
|
1/1 |
absorption oral to dermal |
Step 3) Assessment factors |
|
|
Exposure duration |
2 |
subchronic to chronic |
Interspecies |
4 |
extrapolation systemic effects rat to human |
Intraspecies |
3 |
worker |
DNEL |
Value |
|
For workers |
300 mg/kg x 1 x 1 / (2 x 4 x 3) = 12.5 mg/kg bw/d |
Factor 24
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 13 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 23
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 7.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 40
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 7.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 40
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
Short term exposure general population (systemic effects)
Same considerations as for the worker.
Long term exposure general population (systemic effects)
Oral, inhalatory and dermal
The DNELs for oral, inhalatory and dermal long term exposure are derived from the NOAEL obtained in an oral repeated dose study (BASF 73R0162/03041). In this 2-generation reproduction toxicity study (comparable to the current OECD guideline 416) rats were exposed to 0, 100, 300, 1000 mg/kg bw/day for up to 20 weeks. Effects on liver and kidney weight (with corroborative histopathological findings) were observed in males and females at 1000 mg/kg bw/day. A dose level of 300 mg/kg bw/day is considered as NOAEL.
Long term general population (oral)
Description |
Value |
Remark |
Step 1) Relevant dose-descriptor |
NOAEL: 300 mg/kg bw (OECD 416; oral; rat) |
effects on liver and kidney weight |
Step 2) Assessment factors |
|
|
Exposure duration |
2 |
subchronic to chronic |
Interspecies |
4 |
extrapolation systemic effects rat to human |
Intraspecies |
5 |
General population |
DNEL |
Value |
|
For general population |
300 mg/kg / (2 x 4 x 5) = 7.5 mg/kg bw/d |
Factor 40
Long term general population (inhalation)
Description |
Value |
Remark |
Step 1) Relevant dose-descriptor |
NOAEL: 300 mg/kg bw (OECD 416; oral; rat) |
effects on liver and kidney weight |
Step 2) modification of the starting point |
|
|
|
1/1.15 |
route to route (24h exposure) |
|
50/100 |
absorption oral to inhal. |
Step 3) Assessment factors |
|
|
Exposure duration |
2 |
subchronic to chronic |
Interspecies |
1 |
no interspecies extrapolation for inhal. |
Intraspecies |
5 |
General population |
DNEL |
Value |
|
For general population |
300 mg/kg x 0.5 / (1.15 x 2 x 1 x 5) = 13.0 mg/m³ |
Factor 23
Long term general population (dermal)
Description |
Value |
Remark |
Step 1) Relevant dose-descriptor |
NOAEL: 300 mg/kg bw (OECD 416; oral; rat) |
effects on liver and kidney weight |
Step 2) modification of the starting point |
|
|
|
1/1 |
route to route |
|
1/1 |
absorption oral to dermal |
Step 3) Assessment factors |
|
|
Exposure duration |
2 |
subchronic to chronic |
Interspecies |
4 |
extrapolation systemic effects rat to human |
Intraspecies |
5 |
General population |
DNEL |
Value |
|
For general population |
300 mg/kg x 1 x 1 / (2 x 4 x 5) = 7.5 mg/kg bw/d |
Factor 40
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