3-(triethoxysilyl)propiononitrile

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1956

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1956

Report date:

1956

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

other: LD50

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-(triethoxysilyl)propiononitrile

EC Number:

213-050-5

EC Name:

3-(triethoxysilyl)propiononitrile

Cas Number:

919-31-3

Molecular formula:

C9H19NO3Si

IUPAC Name:

3-(triethoxysilyl)propanenitrile

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS

- Age at study initiation: 5 to 6 weeks

- Weight at study initiation: 90-120 grams

- Fasting period before study: not fasted

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Remarks:

T52-003: 10% dilution in corn oil

Details on oral exposure:

VEHICLE

- Concentration in vehicle: as a 10% dilution


MAXIMUM DOSE VOLUME APPLIED: ca. 5 for 7.95 g/kg dose and ca. 8ml for 3.98 g/kg dose

Doses:

7950 and 3980 mg/kg bw

No. of animals per sex per dose:

3.98 g/kg bw: 5 rats
7.95 g/kg bw: 4 rats

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days

- Frequency of observations and weighing: no data available

- Necropsy of survivors performed: yes

- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: no data available

Statistics:

Thompson's method of calculating the median-effective dose (LD50) was applied to the 14-day mortality data.

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

5 600 mg/kg bw

Based on:

test mat.

Remarks:

median-effect dose, calculated from the 14-day mortality data

Remarks on result:

other: No range is given because there was 100% mortality at 7.95 g/kg bw and 100% survival at 3.98 g/kg bw

Mortality:

All animals administered the higher dose died. No mortalities were seen at the lower dose.

Clinical signs:

other: 3.98 g/kg bw: no data available At 7.95 g/kg bw: Violent convulsions followed the administration of the doses and death ensued in a few hours.

Gross pathology:

3.98 g/kg bw: no data available
At 7.95 g/kg bw: Lungs were hemorrhaged, livers and kidneys mottled and adrenals slightly congested at autopsy.

Other findings:

No data available.

Any other information on results incl. tables

Table 1: Number of animals dead and time range within which mortality occured

Dose (mg/kg bw)	Mortality (# dead/total)			Time range of deaths (day)
	Male	Female	Combined
3.98	0/5	-	0/5	-
7.95	4/4	-	4/4	0

 

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

In an acute oral toxicity study available from an IUCLID summary, claimed to be conducted using a protocol comparable to the now deleted OECD Test Guidelines 401, but predating GLP, the LD50 was determined to be 5600 mg/kg bw/day in male Wistar rats.