Registration Dossier

Administrative data

Description of key information

No in vitro or in vivo skin or eye irritation data are available for 3-(triethoxysilyl)propiononitrile, therefore the available data for the related substance 3-(trimethoxysilyl)propriononitrile have been read across. 
In the available studies, 3-(trimethoxysilyl)proptionitrile was not irritant to rabbit skin or eyes (Thrash, 1981).

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

No in vitro or in vivo skin or eye irritation data are available for 3-(triethoxysilyl)propiononitrile, therefore the available data for the related substance 3-(trimethoxysilyl)propiononitrile have been read across.

In a non-GLP skin irritation study that was similar to OECD 404, minor skin reactions were observed that were not fully reversed in one animal (out of six) at the end of the 7 -day observation period. However, it is likely that this would have been reversed if the study had been extended to the standard 14 -days specified in current guidelines.

In a non-GLP eye irritation study that was similar to OECD 405, minor reactions were reversible in all six test animals by the 48 -hour observation.

The registered substance, 3-(triethoxysilyl)propiononitrile, and the read-across substance, 3-(trimethoxysilyl)propiononitrile, both hydrolyse in water (half lives 7 and 2 hours respectively at pH 7) to form a common silanol hydrolysis product

3-propanenitrilesilanetriol and the corresponding alcohols, ethanol and methanol. Neither alcohol is irritating to rabbit skin, and the read-across is therefore considered valid.

Justification for classification or non-classification

On the basis of the available in vivo data for the related substance 3-(trimethoxysilyl)propiononitrile, the registered substance

3-(triethoxysilyl)propiononitrile is not classified as a skin or eye irritant according to the criteria of EU Directive 67/548/EEC or Regulation 1272/2008.