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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1956
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The study was well documented and meets generally accepted scientific principles, but did not follow current guideline requirements and pre-dates GLP. It does, however, add weight of evidence for the acute toxicity of 3-(triethoxysilyl)propiononitrile.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1956
Report Date:
1956

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Female rats were exposed to substantially saturated vapour of 3-(triethoxysilyl)propiononitrile for a period of 8 hours. Non-guideline study that pre-dates GLP
GLP compliance:
no
Test type:
other: exposure to substantially saturated vapour
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
female
Details on test animals and environmental conditions:
No data available.

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION:

Concentrated vapour was generated at room temperature by passing air at 2.5 liters/minute through a fritted glass 
disc immersed in  50 ml of 3-(triethoxysilyl)propiononitrile.





Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
8 h
Concentrations:
Substantially saturated vapour. Analytical concentration not determined.
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days

Statistics:
No data available.

Results and discussion

Preliminary study:
Concentrations were not measured. One of six rats died.
Mortality:
One out of 6 rats died in response to the exposure.
Clinical signs:
No data available.
Body weight:
No data available.
Gross pathology:
No data available.
Other findings:
No data available.

Any other information on results incl. tables

Inhalation exposure to concentrated vapor generated at room temperature caused the death of 1 of 6 adult female rats.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In a non-guideline study, which pre-dates GLP, exposure of female rats to substantially saturated vapour for 8 hours resulted in the death of one out of six test animals.