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Diss Factsheets
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EC number: 700-282-1 | CAS number: 66922-99-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Not irritating to rabbit skin in vivo.
Not irritating to rat skin in vivo.
Not irritating to rabbit eye in vivo.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
A primary skin irritation study was performed according to OECD Guideline 404 (Sanders, 2010c). The clipped skin in the dorsal trunk area of two New Zealand White rabbits was exposed to 0.5 g of the solid test substance moistened with 0.5 mL distilled water for 4 hours under semi-occlusive conditions. In the first animal two additional skin sites were exposed for 3 minutes and 1 hour. The observation period was 72 hours. Treated skin sites were assessed according to the Draize scheme for primary skin irritation. No skin irritation was observed at any of the examination time points in any of two treated animals.
Within an acute dermal toxicity study performed according to OECD Guideline 402 (Sanders 2010b) groups of five male and five female Wistar rats were dermally exposed to 2000 mg/kg bw test substance moistened with distilled water for 24 hours under semiocclusive conditions. The treated skin sites were examined for primary skin irritation once daily during the 14 -day observation period according to Draize system. No skin irritation was observed in any of the treated animals at any examination time point.
An acute eye irritation study according to OECD guideline 405 has been performed in New Zealand White rabbits (Sanders, 2010d). 0.1 mL of the test substance as it was instilled in one eye of 3 animals and the scores according to Draize were reported after 1, 24, 48 and 72 hours. There were only slight irritations on the conjunctiva, which were fully reversible within 7 days. No clinical signs, abnormal body weight changes or systemic toxicity had been observed.
Justification for classification or non-classification
No classification is warranted according to DSD (67/548/EEC) and CLP (1272/2008/EC) classification criteria for corrosion/irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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