Registration Dossier
Registration Dossier
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EC number: 700-282-1 | CAS number: 66922-99-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Acute oral LD50 rat > 2000 mg/kg bw
Acute dermal LD50 rat > 2000 mg/kg bw
Acute inhalation toxicity: no study required, as the MMAD is > 100 µm
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral toxicity:
An acute oral toxicity study was performed according to OECD Guideline 420 (Sanders, 2010a). Five female Wistar rats were treated with 2000 mg/kg bw test substance in distilled water by single oral gavage. No deaths occurred, no treatment related changes in bodyweight gain and no other clinical signs of systemic toxicity were observed during the 14 day study period. Based on the study results the oral LD50 in rats was greater than 2000 mg/kg bw.
Acute dermal toxicity:
An acute dermal toxicity study was performed according to OECD Guideline 402 (Sanders, 2010b). Groups of five male and five female Wistar rats were dermally exposed to 2000 mg/kg bw test substance moistened with distilled water for 24 hours under semiocclusive conditions. No deaths occurred. One female showed no gain in bodyweight during the first week and bodyweight loss during the second week. One other female showed bodyweight loss during the first week but expected gain in bodyweight during the second week. The remaining animals showed expected gains in bodyweight over the study period. No other clinical signs of systemic toxicity were observed and no skin irritation was observed. Based on the study results the dermal LD50 in rats was greater than 2000 mg/kg bw.
Justification for classification or non-classification
No classification is warranted according to DSD (67/548/EEC) and CLP (1272/2008/EC) classification criteria for acute toxicity.
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