Diphosphoric acid, copper salt

Toxicity to birds

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to birds

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

REPORTING FORMAT FOR THE ANALOGUE APPROACH
For further information please refer to read across justification in IUCLID section 13.

Reason / purpose for cross-reference:

read-across source

Key result

Duration (if not single dose):

14 d

Dose descriptor:

LC50

Effect level:

ca. 1 400 mg/kg bw

Conc. / dose based on:

test mat.

Basis for effect:

mortality

Validity criteria fulfilled:

not applicable

Conclusions:

A LD50 of ca. 1400 mg/kg bw was determined in the key study.

Executive summary:

A LD50 of ca. 1400 mg/kg bw was determined in the key study. The toxicity potential of the element copper was judged to be in the same range for bird as it was determined for rats. Therefore no further test was considered necessary as the toxicity in rats was sufficiently evaluated and results were considered transferable to birds.

Description of key information

For toxicity to birds a LD50 of ca. 1400 mg/kg bw was determined.

Additional information

Data are available on a number of substances containing inorganic copper and read-across is justified on the basis that for the purposes of assessing the ecotoxicology of Copper (II) pyrophosphate (copper(2+) diphosphate) the chemical species of interest is copper. As such studies referring to soluble copper ions from any source are considered to be directly relevant to Copper (II) pyrophosphate. Copper (II) pyrophosphate is considered to contribute to copper toxicity in the environment and as such the data assessment and risk assessment focusses on the copper ion as the phosphate ion is not considered to be toxic.

 

Effects on birds

For toxicity to birds a LD50 of ca. 1400 mg/kg bw was determined in the key study. The toxicity potential of the element copper was judged to be in the same range for birds as it was determined for rats. Therefore no further test was considered necessary as the toxicity in rats was sufficiently evaluated and results were considered transferable to birds.

 

Additional information:

A voluntary risk assessment report of copper and copper compounds has been submitted to the European Chemicals Agency by the European Copper Institute (June 2008). This report is based on the industry initiative to perform a voluntary risk assessment on a substance according to the mechanisms of the implementation of the Existing Substance Regulation (EEC) No 793/93 (ESR). The procedure was agreed by the 11thJoint Meeting of the Competent Authorities for the Implementation of Directive 67/548/EEC and ESR Regulation. Italy has been acting as a reviewing Member State for the substance and the risk assessment report has been reviewed by the Technical Committee on New and Existing Substances (TC NES) according to standard operational procedures of the Committee.