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EC number: 700-204-6
CAS number: 1174627-68-9
An acute skin irritation study was performed with DV-SOLV 1059 in New
Zealand White rabbits. Parameters monitored during this study included
mortality, body weight measurements and clinical observations. The
irritancy of the test item was evaluated according to the Draize method
(OECD No.: 404, 2002). The test item was administered undiluted, at a
single dose of 0.5 ml. Gauze was placed onto the hairless skin of the
rabbit, test item was applied to the gauze, additional gauze was placed
over the test item and an adhesive clear plastic patch applied. The
trunk was wrapped in clear plastic with medical tubing used to hold the
patch in place. The untreated skin of each animal served as control.
After 4 hours, the remaining test item was removed with water at body
temperature. To assess skin irritation, animals were examined at 1, 24,
48 and 72 hours after the patch removal. Additional general examinations
were performed daily. There was no mortality or systemic clinical
changes related to DV-SOLV 1059 administration. There was no effect of
treatment on body weight. At observation one, 24, 48 and 72 hours after
patch removal, there were no observed clinical signs noted on the skin
of the treated animals. As no clinical signs were observed up to 72
hours after patch removal, the study was terminated after the 72 hours
observation. The animals’ individual mean scores (considering readings
at 24, 48 and 72 hours after patch removal) for erythema and oedema were
0.00, 0.00 and 0.00 respectively. According to Directive 2001/59/EC,
DV-SOLV 1059 does not require classification as a skin irritant.
According to the UN Globally Harmonised System of Classification and
Labelling of Chemicals, DV-SOLV 1059 does not require classification as
a skin irritant.
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