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EC number: 700-204-6
CAS number: 1174627-68-9
A study was performed
to assess the acute dermal toxicity of Rhodiasolv Polarclean in the
Wistar strain rat. A group of ten animals (five males and five females)
was given a single, 24 hour, semi-occluded dermal application of the
undiluted test item to intact skin at a dose level of 2000 mg/kg
bodyweight. Clinical signs and bodyweight development were monitored
during the study. All animals were subjected to gross necropsy.
There were no deaths.
Red/brown staining around the snout was noted in two males during the
day of dosing. There were no other signs of systemic toxicity noted.
There were no signs of dermal irritation. Animals showed expected gains
in bodyweight over the study period except for one female which showed
bodyweight loss during the first week but expected gain in bodyweight
during the second week. No abnormalities were noted at necropsy.
The acute dermal
median lethal dose (LD50) of the test item in the Wistar strain rat was
found to be greater than 2000 mg/kg bodyweight.
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