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EC number: 252-558-1
CAS number: 35435-21-3
No toxic effects were observed in the only tested loading rate of 100
96-hour LL50 >100 mg/l
(nominal concentration) (highest concentration tested), mortality of Oncorhynchus
A 96-hour LL50 value
of >100 mg/l has been determined for effects of the test substance on
mortality of Oncorhynchus mykiss, conducted
in accordance with OECD TG 203 but not in compliance with GLP (IBACON,
2001a). The fish were exposed to a filtered suspension of the test
substance prepared at a loading rate of 100 mg/l. The loading rate of
100 mg/l was far above the water solubility of the substance (<0.1
mg/l). Results of a related study conducted under the same project
number but with unfiltered test media resulted in mortalities of the
test organisms that were attributed to the effects of the undissolved
test substance. A parallel exposure to a 100 mg/l test medium that had
been filtered gave a similar result to that reported in this study
(96-hour LL50 >100 mg/l) (IBACON, 2001b).
Based on the hydrolysis
half-life of the test substance (43 hours at pH 7 and
20-25°C, predicted), it is likely that in the absence of
undissolved material the organisms could be exposed to a mixture of the
parent substance and the hydrolysis products. Test
solutions were prepared above the limit of water solubility of the
parent substance. Undissolved material might have been present in the
test solutions as a film on the surface or as hydrolysis resistant
micelles of the parent substance and oligomers in the water body. The
tests with fish have been conducted in filtered and unfiltered test
media. The observations during these tests indicate that toxicity is
observed in unfiltered test media only. Consequently, effects are
associated with undissolved test material. However, a filter is not able
to effectively retain all undissolved monomers and oligomers, therefore
it is possible that the test organisms in the tests with filtered test
media could have been exposed to lower amounts of undissolved material.
The results are supported by
a reliable study with the read-across substance triethoxy(octyl)silane
which is a structural analogue of the registration substance. The
test substance did not achieve any toxicity when tested at the
solubility limit of the substance; the 96-hour LC50 value was
>0.13 mg a.i./l (nominal concentration) (Springborn Smithers,
2008a). The study was conducted in accordance with OECD TG 203 and in
compliance with GLP. The flow-through design of the test means that the
test organisms are likely to have been exposed to the parent substance.
Refer to the discussion in
the IUCLID Section 6 endpoint summary or Section 7.0 of the CSR for
further discussion of the approach to chemical safety assessment for
this registration substance, and justification for read-across used.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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