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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo insect germ cell study: gene mutation
Remarks:
sex-linked recessive lethal (SLRL) assay in D. melanogaster.
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientifically well conducted study, part of the NTP testing program

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Chemical mutagenisis testing in Drosophila. V. Results of 53 coded compounds for the national testing program
Author:
Woodruff R.C., Mason J.M., Valencia R. and Zimmering S.
Year:
1985
Bibliographic source:
Environ. Mutagen. 7, 677-702
Reference Type:
publication
Title:
Unnamed
Year:
1990

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Sex-linked recessive lethal assay
Appropriate statistical evaluations. Cluster analysis by Poisson distribution; normal test of lethal frequencies after clusters removed Glass fiber discs, saturated with the test compound carried a 5% sucrose solution were used to expose males for 3 days in glass shell vials. Males were mated immediately after treatment with 3 new females for each of 3 broods.
GLP compliance:
not specified
Type of assay:
Drosophila SLRL assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzaldehyde
EC Number:
202-860-4
EC Name:
Benzaldehyde
Cas Number:
100-52-7
Molecular formula:
C7H6O
IUPAC Name:
benzaldehyde
Details on test material:
Batch No.: Not specified
Purity: 72-91%

Test animals

Species:
Drosophila melanogaster
Strain:
other: Canton-S wild-type
Sex:
male
Details on test animals or test system and environmental conditions:
None stated

Administration / exposure

Route of administration:
oral: feed
Vehicle:
5% sucrose solution
Details on exposure:
None stated
Duration of treatment / exposure:
72 hours
Frequency of treatment:
exposure was assumed to be constant, via food source.
Post exposure period:
Immediately
Doses / concentrations
Remarks:
Doses / Concentrations:
1150 ppm
Basis:
nominal in diet
No. of animals per sex per dose:
Given as "10-20 animals per vial"
Control animals:
not specified
Positive control(s):
None stated

Examinations

Tissues and cell types examined:
None stated
Details of tissue and slide preparation:
None stated
Evaluation criteria:
Criteria for positive results: if no wild-type males were identified among 20 or more Basc nales or Bascl +/- females, then it was considered a lethal mutation. If a few F2 or F3 wild-type males survived at <5% of Basc males or Bascl +/- females then it was considered a lethal mutation.
Statistics:
None stated

Results and discussion

Test results
Sex:
male
Genotoxicity:
negative
Toxicity:
not specified
Additional information on results:
No information provided

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative
The test substance has no induction of SLRL in Drosophila melanogaster.
Executive summary:

Sex-linked recessive lethal assay: Appropriate statistical evaluations. Cluster analysis by Poisson distribution; normal test of lethal frequencies after clusters removed Glass fiber discs, saturated with the test compound carried a 5% sucrose solution were used to expose males for 3 days in glass shell vials. Males were mated immediately after treatment with 3 new females for each of 3 broods.

The test substance has no induction of SLRL in Drosophila melanogaster.