Registration Dossier

Administrative data

Endpoint:
repeated dose toxicity: other route
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient details available to make a reliability assessment

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Schweinsberg F. et al
Year:
1986
Bibliographic source:
J. Cancer Res. Clin. Oncol, 112, 75

Materials and methods

Principles of method if other than guideline:
Method not determined: reference not located

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat

Administration / exposure

Route of administration:
intraperitoneal
Duration of treatment / exposure:
4-12 wk

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Damage and cell proliferation occurred in the respiratory tract of rats given approximately 2.5 mg/kg bw/day for 4 -12 wk.

Applicant's summary and conclusion