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EC number: 213-561-3
CAS number: 980-26-7
Mean mutation indices in polychromatic erythrocytes:
Vehicle control group -- dose group -- positive control group
24 hours male: 1.0 -- 1.8 -- 23.5
24 hours female: 1.0 -- 1.3 -- 21.1
48 hours male: 1.0 -- 0.7 -- not done
48 hours female: 1.0 -- 0.3 -- not done
72 hours male: 1.0 -- 1.7 -- not done
72 hours female: 1.0 -- 1.0 -- not done
test item was tested in the micronucleus test. The test compound was
suspended in sesame oil and dosed once oral at 2500 mg per kg bodyweight
to male and female mice,
the results of the previously conducted dose range finding assay.
According to the test procedure the animals were killed 24, 48 or 72
hours after administration.
was used as positive control substance and was administered orally at a
dose of 50 mg per kg bodyweight.
number of polychromatic and normochromatic erythrocytes containing
micronuclei was not increased. The ratio of polychromatic/normochromatic
erythrocytes in both male and female animals remained unaffectedby the
treatment with the test item and
was statistically not different from the control values.
induced in both males and females a marked statistically significant
increase in the number of polychromatic cells with micronuclei,
indicating the sensitivity af the system.
results indicate that, under the conditions of the present study,
the test item is not mutagenic in the
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