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EC number: 213-561-3
CAS number: 980-26-7
The acute toxicity of the test item to zebra fish (Brachydanio ratio)
was determined in a 96-hour semi-static test with daily test medium
renewal according to the EU Commission Directive 92/69/EEC, Part C.1
(1992) and the OECD Guideline for Testing of Chemicals No. 203 (1992).
A limit test was performed in accordance with the test guidelines to
demonstrate that the test item has no toxic effect on the test fish up
to the solubility limit of the test item in test water at the loading
rate of 100 mg/L. Due to the low water solubility of the test item, a
dispersion of the test item with the loading rate of 100 mg/L was
continuously stirred at room temperature in the dark over 96 hours.
Then, the dispersion was filtered. The undiluted filtrate with the
maximum concentration of dissolved test item was used as the test
medium. Additionally, a control was tested in parallel.
No analytical determination of the test item concentration in the test
medium was performed since the analysis of the test item in the
filtrates - after comprehensive trials - proved impossible due to the
very low solubility of the test item in test water and the matrix of the
test water. The biological results are based on the loading rate of the
test item of 100 mg/L.
In the control and in the undiluted filtrate with the loading rate of
100 mg/L, no mortality of test fish or other visible abnormalities were
determined during the test period of 96 hours.
The 96-hour NOEC (highest concentration tested without toxic effects
after the exposure perioct of 96 hours) and the 96-hour LC0 of the test
item to zebra fish were determined to be at the loading rate of 100
mg/L. The 96-hour NOEC and the 96-hour LC0 might even be higher but
loading rates of the test item above 100 mg/L were not tested, according
to the test guidelines. The 96-hour LOEC (lowest concentration with
toxic effects), the 96-hour LC50 and the 96-hour LC100 were clearly
higher than the loading rate of 100 mg/L.
In conclusion, the test item had no acute toxic effects on zebra fish up
to its solubility limit in test water at the loading rate of 100 mg/L
under the present conditions of the test.
One test with a read across substance is available. An acute toxicity test on Zebra fish (Brachydanio rerio) had been performed (reliability category 1, compliant to GLP) as a limit test with daily renewal of the test medium (semistatic). The test item is poorly soluble in water. Therfore no analytical determination of the actual test concentration at a nominal concentration of 100 mg/L could be performed. At these test conditions, the test item proved to be non-toxic to Zebra fish (no deaths or any abnormalities in treatment as well as control group):NOEC (96h) = 100 mg/L nominal concentration,LC50 (96h) > 100 mg/L nominal concentration.
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