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EC number: 213-561-3
CAS number: 980-26-7
No effects on body weight gains or clinical signs were observed. The
intradermal injection with Freund's adjuvant (with and without test
substance) caused severe edema as well as indurations and encrustations.
The application sites treated with Freund's adjuvant without the test
substance showed severe erythema; the sites treated with the test
substance showed slight edema. The injection sites treated with the test
substance in Freund's adjuvant and in the vehicle were discolored pink,
therefore, erythema formation was not assessable. Intradermal injections
of the vehicle alone exhibited very slight erythema and edema. Due to
these strong irritation reactions of the skin, treatment with 10% sodium
dodecylsulfate was not done on day 7. Irritation readings during
Dermal Induction treatment (day 15)
Escort group animals 16 17 18 19 20
1. reading (48 hours)
Erythema 0 0 0 0 0
Edema 0 0 0 0 0
Pink discoloration x x x x x
2. reading (72 hours)
After the removal of the patches at day 10, severe erythema (only in the
control group) and oedema, indurated and encrusted skin as well as
necrosis were observed at the sites previously treated with Freund's
Adjuvant. Additionally, the treated skin was disoloured pink in the
animals of the treatment group, therefore erythema formation was not
assessable. The application sites treated with the test substance in the
vehicle showed slight oedema and indurations. No signs of irritation
were observed at the application sites treated with the vehicle alone.
Skin readings after challenge treatment (day 29)
Control animals No. 1 2 3 4 5
Treatment animals No. 6 7 8 9 10 11 12 13 14 15
Erythema 0 0 0 0 0 0 0 0 0 0
Edema 0 0 0 0 0 0 0 0 0 0
Pink discoloration x x x x x x x x x x
Although the skin surface was discolored light pink, possible
erythema formation was assessable. No signs of irritation were observed
in the control and the treatment group 24 and 48 hours after removal of
the occlusive bandage.
sensitizing properties of the test item was performed in female Guinea
pigs according to the method of MAGNUSSON & KLIGMAN. Intradermal
induction was performed using 1 % test item in semi-liquid paraffin.
Dermal induction was carried out with 25 % test item in petrolatum.
Challenge treatment were carried out with 5 % test item in petrolatum. The
challenge treatment caused no skin reaction in the ten animals of the
treatment group or in the five control animals. Based
on the results of this study the test item showed no evidence for
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