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Administrative data

Endpoint:
nanomaterial dustiness
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Remarks:
according to DIN EN 17199-3

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: DIN EN 17199-3
Version / remarks:
measurement of dustiness of bulk materials that contain or release respirable NOAA or other respirable particles - Part 3: Continuous drop method
Deviations:
yes
Remarks:
1 meaurement performed
GLP compliance:
no
Type of method:
continuous drop
Sampling:
The test material was used without further treatment (e.g. drying). 72.3 g (238.38 cm3) test material are used for the measurement, dosing rate: 7.23 g/min

Test material

Constituent 1
Chemical structure
Reference substance name:
5,12-dihydro-2,9-dimethylquino[2,3-b]acridine-7,14-dione
EC Number:
213-561-3
EC Name:
5,12-dihydro-2,9-dimethylquino[2,3-b]acridine-7,14-dione
Cas Number:
980-26-7
Molecular formula:
C22H16N2O2
IUPAC Name:
2,9-dimethyl-5,12-dihydroquino[2,3-b]acridine-7,14-dione
Test material form:
solid: nanoform

Results and discussion

Dustiness indexopen allclose all
Key result
Mean:
434 451.5 other: 1/mg
Remarks on result:
other: dustiness index as number of airborne particles per mg in the nanoscale (10 nm - 100 nm)
Mean:
59 265.7 other: N/cm3
Remarks on result:
other: number of airborne nanoparticles per cm3

Any other information on results incl. tables

measurement duration: 10 min

temperature: 28°C, rel. air humidity 51 %

The cleaned, almost particle-free air had a total particle count of 5 particles/cm3 in the range of 10 nm - 417 nm, the nanoscale fraction (10 - 100 nm) contained 3 particles/cm3.

table 1: summary SMPS (sanning mobility particle sizer)

Range [nm]

Mean [nm]

Concentration [N/cm3]

ICD[1/mg]

ECD[1/mg x s]

10 - 100

55.3

59265.7

434451.5

724.1

100 - 417

206.2

108380.9

794493.7

1324.2

10 - 417

152.8

167646.7

1228945.2

2048.2

ICD: dustiness index as number of airborne particles per mg

ECD: emission rate as number of particles per mg per second

mean: average particle diameter in nm

N: number of airborne particles

table 2: summary OPS (optical particle sizer)

Range [µm]

Mean [µm]

Concentration [N/cm3]

ICD[1/mg]

ECD[1/mg x s]

0.3 - 10

4.9

810.1

5938.2

9.9

Applicant's summary and conclusion

Executive summary:

The dusting behaviour of the test material was investigated using DIN EN 17199 -3: 2019 -12 "workplace exposure - measurement of dustiness of bulk materials that contain or release respirable nano objects and their aggregates and agglomerates or other respirable particles- Part 3: Copntinuous drop method".

The dust released by the falling test material was measured by a scanning mobility particle sizer (SMPS, 10 - 417 nm) and an optical particle sizer (3 - 10 µm). The counterflow was provided by cleaned, almost particle-free air.

The SMPS counted 167646.7 particles per cm3 (in the nanoscale (10 - 100 m) 59265.7 particles per cm3) corresponding to a dustiness index of 1228945.2 particles per mg (in the nanoscale (10 - 100 nm) 434451.5 particles per mg). The mean size of the nanoparticles was 55.3 nm, the mean size of particles in the range 10 - 417 nm was 152.8 nm.

The OPS (0.3 - 10 µm) counted 810.1 particles per cm3 corresponding to a dustiness index of 5938.2 particles per mg. The mean size of the particles was 4.9 µm.