Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Acute toxicity data
Author:
Anon.
Year:
1996
Bibliographic source:
Journal of the American College of Toxicology, Vol. 15, Suppl. 1, S22-S23

Materials and methods

GLP compliance:
not specified
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
5,12-dihydro-2,9-dimethylquino[2,3-b]acridine-7,14-dione
EC Number:
213-561-3
EC Name:
5,12-dihydro-2,9-dimethylquino[2,3-b]acridine-7,14-dione
Cas Number:
980-26-7
Molecular formula:
C22H16N2O2
IUPAC Name:
2,9-dimethyl-5,7,12,14-tetrahydro-5,12-diazapentacene-7,14-dione
Test material form:
not specified

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
water
Duration of exposure:
24 h
Doses:
3 g/kg of the test article (in the form of an aqueous slurry)
No. of animals per sex per dose:
2 males and 2 females
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 3 000 mg/kg bw
Remarks on result:
other: no animals died within the 14 day observation period

Any other information on results incl. tables

No mortality was observed at 3 g/kg and no unusual behavioral, systemic reactions or gross pathologic alterations were observed. Body weight gains were within normal range of growth.

Applicant's summary and conclusion

Conclusions:
Pigment Red 122 caused no mortality in male and female rabbits after a single dermal application of 3000 mg/kg bw.