Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 206-058-5 | CAS number: 298-12-4
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- publication
- Title:
- Glyxoylic acid in ethylene glycol poisoning
- Author:
- Garibotto G et al.
- Year:
- 1 988
- Bibliographic source:
- Nephron 48: 248-249
Materials and methods
- Study type:
- poisoning incident
Test guideline
- Qualifier:
- no guideline required
Test material
- Reference substance name:
- Glyoxylic acid
- EC Number:
- 206-058-5
- EC Name:
- Glyoxylic acid
- Cas Number:
- 298-12-4
- Molecular formula:
- C2H2O3
- IUPAC Name:
- 2-oxoacetic acid
Constituent 1
Method
- Details on exposure:
- A 36-y old man was referred to the hospital for ingestion of 500 ml of a window cleaner containing 12.5% ethylene glycol and 200 ml raw ethanol.
- Examinations:
- glyoxylic acid was determined in whole blood by high performance liquid chromatography.
Results and discussion
- Results of examinations:
- Basal blood level for Glyoxylic Acid were 62.9 µmol/L, a value greatly exceeding both the levels reported in normal subjects in plasma (1 ± 1.5 µmol/L) and those found in whole blood of healthy volunteers (3.1 ± 2 µmol/L). Additionally, the incomplete dialysance of Glyoxylic Acid suggests, that Glyoxylic Acid binds to plasma proteins (Garibotto et al., 1988).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
