Registration Dossier
Registration Dossier
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EC number: 206-058-5 | CAS number: 298-12-4
Biodegradation in water and sediment: simulation tests
Administrative data
- Endpoint:
- biodegradation in water and sediment: simulation testing, other
- Type of information:
- other: Literature data
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Literature data
Data source
Reference
- Reference Type:
- publication
- Title:
- Fermentative degradation of glyoxylate by a new strictly anaerobic bacterium
- Author:
- Friedrich M., Schink B.
- Year:
- 1 991
- Bibliographic source:
- Arch Microbiol., 156, 392-397
Materials and methods
- Principles of method if other than guideline:
- A new strictly anaerobic, gram-negative, non-spore forming bacterium, Stain PerGLx1 was enriched and isolated from marine sediment samples with glyoxylate as sole carbon and energy source.
The aim of this study was to determine the fermentative degradation of glyoxylate by a new strictly anaerobic bacterium to carbon dioxide, hydrogen and glycolate. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Glyoxylate
- IUPAC Name:
- Glyoxylate
Constituent 1
Study design
- Oxygen conditions:
- anaerobic
- Inoculum or test system:
- other: Strain PerGlx1
Results and discussion
- Details on results:
- The guanine-plus-cytosine content of the DNA was 44.1 +/- 0.2 mol %.
Glyoxylate was utilized as the only substrate and was stechiometrically degraded to carbon dioxide, hydrogen, and glycolate.
An acetyl-CoA and ADP-dependent glyoxylate converting enzyme activity, malic enzyme, and pyruvate synthetase were found at activities sufficient for growth (>= 0.25 U x 25 mg protein-1).
These findings allow to design a new degradation pathway for glyoxylate: glyoxylate is condensed with acetyl-CoA to form malyl-CoA; the free energy of the thioester linkage in malyl-CoA is conserved by substrate level phosphorylation.
Part of the electrons released during glyoxylate oxidation to CO2 reduce a small fraction of glyoxylate to glycolate.
Applicant's summary and conclusion
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