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EC number: 270-790-1 | CAS number: 68478-10-4 A complex combination of hydrocarbons obtained by the distillation of debenzenized light steam-cracked naphtha. It consists predominantly of cyclic olefinic and aromatic hydrocarbons having carbon numbers predominantly in the range of C8 through C16 and boiling in the range of approximately 130°C to 300°C (226°F to 572°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 September - 18 October 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as unpublished report, no restictions, fully adequate for assessment.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Doses of DCPD 75%: 500, 794, 1260 & 2000 mg/kg/bw
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Details on test material:
- - Name of test material (as cited in study report): DCPD 75%
- Physical state: clear, yellow-coloured liquid
- Composition of test material, percentage of components: 71.1% endo dicyclopentadiene, 0.8% exo dicyclopentadiene, 1.4% m-bicyclozonadiene, 15.2% CPD-MCPD codimers, 0.3% tricyclopentadiene, 1.3% CPD-butadiene codimer, 0.3% CPD-piperylene codimer, 0.3% CPD-isoprene codimer, <0.1% benzene , remainder misc. hydrocarbons.
- Specific gravity: 0.971
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna (UK) Ltd., Wyton, Huntingdon, Cambridgeshire
- Age at study initiation: 5-8 weeks
- Weight at study initiation: males 120-146 g; females 120-150 g
- Fasting period before study: overnight
- Housing: In groups of up to 5, sexes separately in solid floor polypropylene cages with sawdust bedding.
- Diet: Rat and Mouse Expanded Diet No. 1 (Special Diet Services Ltd., Witham, Essex, UK) ad libitum (except for overnight fast immediately prior to dosing and approximately 2 hours after dosing)
- Water: Mains drinking water ad libitum
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-21
- Humidity (%): 45-68
- Air changes (per hr): approx 15
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: From: 22 September 1988 To: 18 October 1988
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Maximum dose volume applied: 2.06 mL/kg
Minimum dose volume applied: 0.51 mL/kg - Doses:
- 500, 794, 1260 and 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observed 1 and 4 hours after dosing and once daily thereafter. Body weights recorded on day of dosing (day 0), days 7, 14 or at death.
- Necropsy of survivors performed: yes - Statistics:
- The acute oral LD50 and 95% confidence limits calculated using the probit method.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 590 mg/kg bw
- 95% CL:
- 393 - 886
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 512 mg/kg bw
- 95% CL:
- 227 - 1 155
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 676 mg/kg bw
- 95% CL:
- 444 - 1 030
- Mortality:
- All deaths occurred one or two days following dosing. There were 2, 4, 5 and 5 male deaths and 1, 2, 5 and 5 females deaths in the 500, 794, 1260 and 2000 mg/kg bw groups respectively.
- Clinical signs:
- other: Hunched posture, piloerection, lethargy and decreased respiratory rate were present in all animals during the day of dosing. Ptosis was occasionally noted in animals dosed with 794 and 1260 mg/kg during this period. All rats dosed with 2000 mg/kg had ptos
- Gross pathology:
- Haemorrhagic lungs, dark liver and sloughing of the non-glandular gastric epithelium was seen in decedents. No abnormalities were seen in animals killed at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- other: Harmful if swallowed
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 and 95% confidence limits of DCPD 75% were calculated to be 590 (393 - 886) mg/Kg bw for males and females combined; 512 (227 - 1155) mg/Kg bw for males and 676 (444 - 1030) mg/Kg bw for females.
- Executive summary:
Groups of 5 male and 5 female Sprague Dawley rats (fasted overnight) were dosed by gavage at levels of 500, 794, 1260 or 2000 mg/Kg DCPD and were observed daily for 14 days after dosing. At the 4 hour observation period rats dosed with high levels of DCPD (1260 or 2000 mg/Kg bw) had hunched posture, piloerection, lethargy and decreased respiratory rate, with ptosis and occasional signs of ataxia seen in those dosed at 2000 mg/Kg bw . All rats dosed at 1260 or 2000 mg/Kg bw died one or two days after dosing. Haemorrhagic lungs, dark liver and sloughing of the non-glandular gastric epithelium was seen in decedents.
The LD50 was calculated to be 590 mg/Kg bw (male/female), 512 mg/Kg bw for males and 676 mg/Kg bw for females.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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