Registration Dossier

Diss Factsheets

Toxicological information

Endpoint summary

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result: 
Dicyclopentadiene is rapidly absorbed, metabolised and eliminated.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

The toxicokinetics of dicyclopentadiene has been evaluated in rats, mice and dogs (Litton Bionetics, 1976). Elimination from plasma was biphasic in all three species; terminal half lives were 18 to 27 hours. Radioactivity was rapidly and widely distributed into tissues in all three species; the highest concentrations were found in the body fat, adrenal glands and urinary bladder in the rat; in the urinary bladder, gall bladder and body fat in the mouse; and in the bile, gall bladder and bladder in the dog. In all three species, the majority of the radioactivity was excreted in the urine. Urinary radioactivity was present as 6 -7 components; conjugates but no unchanged dicyclopentadiene were present.

A further study was carried out in a lactating Jersey cow (Ivie, 1980). On the basis of this study it was concluded that exposure of livestock to small quantities of dicyclopentadiene would not result in detectable contamination of the milk or meat.