Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 270-790-1
CAS number: 68478-10-4
A complex combination of hydrocarbons obtained by the distillation of debenzenized light steam-cracked naphtha. It consists predominantly of cyclic olefinic and aromatic hydrocarbons having carbon numbers predominantly in the range of C8 through C16 and boiling in the range of approximately 130°C to 300°C (226°F to 572°F).
Some information in this page has been claimed confidential.
most recent analyses incorporating exposure from high exposure events
and utilising a different reference group indicate a much weaker
association between leukaemia and benzene exposure than originally
reported by Glass et al. (2003). However, they still predict a large
excess of leukaemia in the Health Watch cohort as just over half of
control subjects had cumulative exposures greater the cut off point for
the reference group. There is no corresponding increase in leukaemia
incidence in the Health Watch cohort. The latest update by Gun et al.
(2006) reported an SIR of 1.07 (95% CI 0.74-1.49, 34 observed) for
leukaemia and an SIR of 0.97 (95% CI 0.42-1.91, 8 observed) for acute
(fixed-effects) logistic regression, leukaemia by cumulative exposure to
benzene (ppm-years) (Table based on Glass et al, 2005; Table 2).
Cumulative exposureOR (95% CI)
Cumulative exposure including
high exposure events OR (95% CI)
nested case-control study investigated a possible association between
benzene exposure and lymphohaematopoietic cancers noted in male members
of the Health Watch cohort. Exposure was retrospectively estimated for
each occupational history and shown to be low - 85% of cumulative
exposure estimates were < 10 ppm years.
strong association between leukaemia and modest benzene exposure was
demonstrated, but non-Hodgkin lymphoma and multiple myeloma were not
associated with benzene exposure. Leukaemia risk was increased for
subjects with greater than 16 ppm years cumulative exposure when high
exposure events were incorporated (OR 7.79) or with greater than 0.8 ppm
intensity of highest exposure. However, the dose response curve is
inconsistent and very sensitive to the choice of reference group, cut
off points for categorical groupings and assumptions made about high
exposure events. Only ANLL was significantly associated with benzene
exposure, but there was limited information available to assess
associations for leukaemia subtypes and no analyses incorporating high
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again