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EC number: 270-790-1
CAS number: 68478-10-4
A complex combination of hydrocarbons obtained by the distillation of debenzenized light steam-cracked naphtha. It consists predominantly of cyclic olefinic and aromatic hydrocarbons having carbon numbers predominantly in the range of C8 through C16 and boiling in the range of approximately 130°C to 300°C (226°F to 572°F).
Ototoxicity is known to occur following
repeated inhalation exposures to toluene, styrene and ethylbenzene.
Effects on colour vision in humans have also been reported for toluene
and styrene. These effects are considered in the overall risk assessment
for repeated dose exposures in section 5.6.3.
specific components toluene, styrene and ethylbenzene are recognised as
ototoxicants following repeated inhalation exposure. Effects
on colour vison have also been reported for toluene and styrene.
is ototoxic in rats producing loss of cochlea hair cells which is
considered to be an irreversible effect. However, effects have been
insufficiently documented to enable determination of a NOAEC. Hearing
loss has been reported in humans, especially when toluene exposure is
associated with high exposure concentrations and a noisy environment. In
addition there have been reports of disturbances of colour vision.
Several epidemiology studies (Schaper et al, 2003, 2004) suggest that
adverse changes do not occur when exposures are maintained below the
current indicative occupational exposure limit of 50 ppm (188 mg/m3).
inhalation exposure to ethylbenzene causes ototoxicity in rats (Gagnaire
et al, 2007). Auditory dysfunction is characterised by an elevation of
hearing thresholds in the mid frequency range and loss of cochlear outer
hair cells, the sensory cells in the inner ear. Hearing loss and cell
damage increased with exposure concentrations. The NOAEC for ototoxicity
was extrapolated to be 114 ppm (500 mg/m³) based on destruction of outer
exposure to styrene in animals produces ototoxicity in rats. The EU
transitional RAR has identified a NOAEC of 50 ppm in humans based on
colour vision discrimination effects in occupationally exposed workers.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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