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EC number: 278-770-4
CAS number: 77804-81-0
The primary skin irritation potential of the test item was
investigated according to OECD test guideline no 404.The test item (0.5
g pasted with 0.5 ml of distilled water) was applied to the intact skin
of three New Zealand White rabbits under semi-occlusive conditions for
four hours. The scoring of skin reactions was performed 1, 24, 48 and 72
hours after removal of the test item.
No clinical signs of systemic toxicity were observed in the animals
during the study and no mortality occurred. A light yellow staining was
produced by the test item on the treated skin of the three male rabbits
This persisted up to the 24-hour reading. A very slight erythema was
noted in all animals at the 1 -hour and the 24 -hour reading (maximum
score observed: 1), but was no longer present at the 48 -hour reading.
Therefore, the overall erythema score in all animals was 0.33 and the
overall edema score was 0.
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