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EC number: 278-770-4
CAS number: 77804-81-0
Based on the available
data base on C.I. Pigment Yellow 180 relevant information exists to make
a qualitative evaluation of the toxicokinetic profile of this compound.
This is in line with animal welfare considerations because additional
animal tests can be avoided by such an evaluation. The substance is
available in non-nano- as well as nano-form. The available data have
been generated with non-nano material, but the conclusions drawn are
considered valid for the nano form as well, because the material is
chemically identical and the physical properties are widely overlapping.
The results of basic
toxicity testing give no reason to anticipate unusual characteristics
regarding the toxicokinetics of C.I. Pigment Yellow 180. The data
indicate that there is no relevant dermal absorption. C.I. Pigment
Yellow 180 is not absorbed from the gastro-intestinal tract in
toxicologically significant amounts. Indications of a bio-accumulative
potential as well as metabolism towards genotoxic sub-structures do not
exist. Excretion of small amounts of possibly systemically available
C.I. Pigment Yellow 180 and/or metabolites via faeces is likely.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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