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EC number: 278-770-4
CAS number: 77804-81-0
The test item was
tested in a micronucleus test conducted similar to OECD guideline 474.
The test compound was administered
orally by gavage to male and female mice. The following doses were tested:
0, 50, 500 and 5000 mg per kg bodyweight.
animals were treated twice within 24 h with the test compound and
according to the test procedure
the animals were killed 6 hours after the second administration of the test
incidence of micronucleated polychromatic erythrocytes of the animals
with the test item was within the normal range of the negative control.
of normochromatic erythrocytes containing micronuclei was not increased
compared to the control animals.The
ratio of polychromatic/normochromatic erythrocytes in both male and
remained unaffected by the treatment.
positive control (Cyclophosphamide = EndoxanR)
yielded positive results and therefore indicating
the sensitivity of the system.
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