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EC number: 278-770-4
CAS number: 77804-81-0
Pigment Yellow 180 did not reveal any irritation potential on the skin
of rabbits, tested in this study according to OECD test guideline no.
404 and GLP conditions.
Pigment Yellow 180 did not reveal any remarkable irritation potential on
the eyes of rabbits,with standard methods regarding dosing, exposure
duration, scoring system and reading time points. Therefore, it is
concluded that the substance is not irritating to eyes.
The primary skin irritation potential of the test item was
investigated according to OECD test guideline no 404.The test item (0.5
g pasted with 0.5 ml of distilled water) was applied to the intact skin
of three New Zealand White rabbits under semi-occlusive conditions for
four hours. The scoring of skin reactions was performed 1, 24, 48 and 72
hours after removal of the test item.
No clinical signs of systemic toxicity were observed in the animals
during the study and no mortality occurred. A light yellow staining was
produced by the test item on the treated skin of the three male rabbits
This persisted up to the 24-hour reading. A very slight erythema was
noted in all animals at the 1 -hour and the 24 -hour reading (maximum
score observed: 1), but was no longer present at the 48 -hour reading.
Therefore, the overall erythema score in all animals was 0.33 and the
overall edema score was 0.
material was subject to a test of eye irritancy according to FDA
guidelines (Fed. Reg. Vol. 38, No. 187, p. 27019, 1973). 100 mg of
in polyethylenglycol were applied to one eye of six animals each. The
eyes were washed 24 h after application and eye responses were noted for
72 h after start of the exposure. Only slight effects could be observed,
conjunctiva redness score of 1 in 5/6 animals at the 24 h reading and in
2/6 animals at the 48 h reading. This effect was fully reversible within
72 h. Only slight other effects (iridial effects, score = 1 in 3/6
animals at the 1 h reading; Cornea score = 1 in 1/6 animals at 1 h
reading; Chemosis score = 1 in 6/6 animals at the 1 h reading and in 3/6
animals at the 7 h reading) were observed after 1 and 7 h, these effects
were reversible within 24 h.
No calssification: No adverse effects observed.
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