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EC number: 278-770-4
CAS number: 77804-81-0
Single application of 5000 mg/kg bw of the test substance did not cause
lethality in female Wistar rats during the 14 day observation period,
resulting in a LD50 > 5000 mg/kg bw.
Exposure of male and female Wistar rats to 1274 mg/m³ test item (i.e.
maximum technically feasible concentration) for 4 hours did not result
in the death of the animals during a 14 day observation period,
resulting in a LC50 value of > 1274 mg/m³.
Female Wistar rats were subjected to test acute oral toxicity. 5000
mg/kg bw of the test substance were administered by gavage. No animal
died under these conditions during the 14 -day observation period, thus
leading to a LD50 > 5000 mg/kg bw.
- no deaths occurred
- during dust exposure rats showed unsteady breathing
- behaviour of the rats was normal during the 14 days observation period
- body weight development was normal during the 14 days observation
- no gross organ changes were seen at necropsy
Acute inhalation toxicity of the test item has been investigated in male
and female Wistar rats. Mean dust exposure concentration was 1274 mg
test substance per cubic metre (i.e. maximum technically feasible
concentration; exposure ranged from 521 to 2511 mg/ cubic metre). The
rats were exposed for 4 hours, nose only. All animals survived the 14
day observation period. No macroscopic visible changes were observed at
necropsy at the end of the observation period, resulting in a LC50 value
of > 1274 mg/m³ for the inhalation of dust.
No classification: No adverse effects observed
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