Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD guideline 402
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
412-440-4
EC Name:
-
Cas Number:
2725-22-6
Molecular formula:
C33-H39-N3-O2
IUPAC Name:
2-[4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl]-5-(octyloxy)phenol

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
physiological saline
Controls:
not specified
Amount / concentration applied:
2000 mg
Duration of treatment / exposure:
24 h/ 48hs/72hrs
Observation period:
72 hrs
Number of animals:
10
Details on study design:
not specified

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
edema score
Basis:
mean
Time point:
24 h
Score:
0
Max. score:
0
Remarks on result:
other: Max. duration: 0d; Max.value at end of observation period:0
Irritation parameter:
erythema score
Time point:
24/48/72 h
Remarks on result:
other: Not available
Irritation parameter:
edema score
Time point:
24/48/72 h
Remarks on result:
other: Not available
Irritant / corrosive response data:
not specified
Other effects:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
Skin irritation study was performed according to OECD guideline 402 to determine the toxic nature of test chemical. 10 New Zealand White rabbits were dosed at 2000 mg/kg bw for 24hr, 48hrs and 72hrs. The test chemical was dissolved in physiological saline. No edema or erythema was observed after 72hrs. Thus the test chemical was considered to ‘Not Irritating’.
Executive summary:

Skin irritation study was performed according to OECD guideline 402 to determine the toxic nature of test chemical. 10 New Zealand White rabbits were dosed at 2000 mg/kg bw for 24hr, 48hrs and 72hrs. The test chemical was dissolved in physiological saline. No edema or erythema was observed after 72hrs. Thus the test chemical was considered to ‘Not Irritating’.