Registration Dossier

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Endpoint conclusion:
no study available (further information necessary)
Additional information

There is no data on the toxicity to reproduction for this substance. A testing proposal has been submitted for the substance 2 -(2 -(2-methoxyethoxy)ethoxy)ethanol and the results will be read across to this substance using a category approach with appropriate additional bridging studies that are currently in progress.

Effects on developmental toxicity

Effect on developmental toxicity: via oral route
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
800 mg/kg bw/day
Effect on developmental toxicity: via dermal route
Endpoint conclusion:
no adverse effect observed
Additional information

No developmental toxicity data is available for this substance. Based on observations from other members of the category, and taking into account molecular weight differences, it is possible to estimate the likely NOAELs for the developmental toxicity in both rats and rabbits will exceed 1000mg/kgbw/day and therefore no adverse effects are observed up to the limit dose.

Justification for classification or non-classification

There is no indication of fertility effects at a dose of 1000mg/kg bw or below. There is no indication of developmental toxicity effects at a dose of 1000mg/kg bw or below or effects that occur below the level where maternal toxicity is also observed. There is no indication that reproductive toxicity is a characteristic of this substance and that classification is warranted for this end point.

Additional information

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