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EC number: 203-978-9
CAS number: 112-50-5
A limited number of acute toxicity studies are available in fish. These
clearly show that the substance 2-(2-(2-ethoxyyethoxy) ethoxy)ethanol is
practically non-toxic to fish. The LD50 was always in excess of the
maximum tested dose. The substance and its main metabolite have been
tested in the zebrafish embryotoxicity study and neither showed any
evidence of toxicity up to the maximum tested dose of 10mM (1780mg/L for
2 -(2 -(2 -ethoxyethoxy)ethoxy ethanol.
The position is similar in invertebrates. A limited number of studies
again clearly show that the substance
2-(2-(2-ethoxyyethoxy)ethoxy)ethanol is practically non-toxic to daphnia
and artemia. The LD50 was always in excess of the maximum tested dose.
There is no measured value available for the toxicity to algae for this
substance. There is however measured data for two substances either side
of it in the homologous series of these triethylene glycol ethers. A
full and detailed justification for a category approach for meeting the
individual data requirements for glycol ethers is included as an
attachment in chapter 13 to this dossier. For this specific end point,
this approach shows a clear trend of decreasing toxicity to aquatic
species with reducing length of the alkyl chain length of the alcohol
used to produce the glycol ether. Interpolation from the results of
other glycol ethers within the same homologous family of triethylene
glycol ethers can be considered a valid approach to meeting the data
requirements of this substance. 2-(2-(2 -methoxyyethoxy)ethoxy)ethanol
(TEGME) has a measured 72hr EC0 of >500mg/l (maximum tested dose)
whereas 2-(2-(2 -butoxyyethoxy)ethoxy) ethanol has a measured 72 hr EC10
of 613mg/l.. The value for 2-(2-(2-ethoxyyethoxy) ethoxy)ethanol (TEGEE)
will fall somewhere in between. These values are consistent with those
predicted by the QSAR ECOSAR, with the model being somewhat more
conservative. On this basis, the value chosen for the EC50 and NOEC/EC10
values are those predicted by the QSAR, which also happen to be similar
to the lowest of the values from the surrogate substances.
Studies are available on sewage sludge micro-organisms and a broad
spectrum micro-organism mixture. Both studies showed that the substance
is practically non-toxic to micro-organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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