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EC number: 203-978-9
CAS number: 112-50-5
Measured data: TEGBE surrogate: 72hr EC10 (growth rate) = 613mg/l, TEGME, EC10>500mg/l.QSAR value (EC50): 7000mg/l.
There is no measured value available for the toxicity to algae for this
substance. There is however measured data for two substances either side
of it in the homologous series of these triethylene glycol ethers. A
full and detailed justification for a category approach for meeting the
individual data requirements for glycol ethers to support read across is
included as an attachment in chapter 13 to this dossier. For this
specific end point, this approach shows a clear trend of decreasing
toxicity to aquatic species with reducing length of the alkyl chain
length of the alcohol used to produce the glycol ether. Interpolation
from the results of other glycol ethers within the same homologous
family of triethylene glycol ethers can be considered a valid approach
to meeting the data requirements of this substance.
2-(2-(2 -methoxyyethoxy)ethoxy)ethanol (TEGME) has a measured 72hr EC0
of >500mg/l (maximum tested dose) whereas 2-(2-(2
-butoxyyethoxy)ethoxy)ethanol has a measured 72 hr EC10 of 613mg/l.. The
value for 2-(2-(2-ethoxyyethoxy)ethoxy)ethanol (TEGEE) will fall
somewhere in between. The predicted values for the logkow using the
ECOSAR QSAR are shown below:
Measured values (mg/l)
QSAR values (mg/l)
It can be seen that the QSAR is slightly conservative. The key value for
the EC50 (rounded to 2 significant figures) is taken from the QSAR,
justified by the supporting experimental data from surrogate substances
that suggest that the QSAR is conservative and over estimates toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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