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EC number: 203-978-9
CAS number: 112-50-5
Results for 0 -24 and 24 -48 hour collection periods combined. Note that
the figure for DEG also includes the amount detected as glycolic acid,
since this is a known metabolite of DEG:
The tables below show the amounts collected over the two different time
periods for (average of three animals):
0 – 24hr
24 – 48hr
In a study to examine the metabolism 2 -(2
-(2-methoxyethoxy)ethoxy)ethanol, SD rats were given a single oral dose
of 1000 and the urine collected over two 24 hour periods for analysis
for a number of expected metabolites. The dominant metabolite was 2 -(2
-(2-methoxyethoxy)ethoxy)acetic acid, which accounted for 81% of the
original dose. Unmetabolised 2 -(2 -(2-methoxyethoxy)ethoxy)ethanol and
its glucoronide conjugate, triethylene glycol, methoxyethoxyethoxyacetic
acid were also found at levels of 1 -5% . In addition, the metabolite
methoxyacetic acid was found, the amount accounting for 0.5% of the dose
of 2 -(2 -(2-methoxyethoxy)ethoxy)ethanol given. This demonstrates that
oxidation of the hydroxyl function is the dominant metabolic pathway but
small amounts of the substance are metabolised by cleavage of the ether
linkage. The study also showed that 100% of the dose of 2 -(2
-(2-methoxyethoxy)ethoxy)ethanol was eliminated within 24 hours in the
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