Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Not a GLP or O.E.C.D. Testing Guideline study with few details on experimental dosing and results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Vinyl 2-ethylhexanoate
EC Number:
202-297-4
EC Name:
Vinyl 2-ethylhexanoate
Cas Number:
94-04-2
Molecular formula:
C10H18O2
IUPAC Name:
ethenyl 2-ethylhexanoate

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 hours
Doses:
16.0 and 8.0 ml/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
Rabibts are exposed for 24 hours to test material retained under impervious sheeting on the clipped, intact skin of the trunk. After the contact period the excess fluid is removed and observations are made at 1 hour, 7 days and 14 days.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 16 mL/kg bw
Mortality:
Males: 1 of 5 died at the 16.0 ml/kg dose; Females: 2 of 5 died at the 16.0 ml/kg dose. There were no mortalities at the 8.0 ml/kg dose.
Clinical signs:
other: Sluggishness on day one of high dose with recovery of one at 2 days.
Gross pathology:
Victims: lungs of 1 bright red, intestines of 1 hemorrhaged.
Survivors: lungs of 1 dark red; kidneys of 1 tan

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information
Conclusions:
The acute dermal LD50 for rabbits was >16.0 ml/kg.
Executive summary:

Two groups of rats (five males and five females/group) were dermally exposed toVinyl 2 -ethylhexanoate (16.0 and 8.0 ml/kg per group) under occlusion for 24 hr. The obsrvation period was 14 days. The application of vinyl 2 -ethylhexanoate at doses of 16.0 and 8.0 ml/kg to skin of rat for 24 hr produced an LD50 of >16.0 ml/kg.