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EC number: 202-297-4
CAS number: 94-04-2
IntroductionThe Toxicity to Activated Sludge in a Respiration Inhibition Test study design requires the test vessels to be subjected to aeration using continuous aeration by compressed air or intense stirring to maintain the dissolved oxygen concentration in the vessels above 60% saturation and to maintain the sludge flocs in suspension.A solubility, volatility and preliminary test with analytical analysis was initially performed which showed that the test item was extremely volatile over a 70 minute period. The study was therefore cancelled.
Preliminary Solubility WorkA nominal amount of test item (100 mg) was dispersed in reverse osmosis water (1 L) with the aid of shaking by hand for approximately 1 minute followed by ultrasonication for 30 minutes and then high shear mixing at approximately 7500 rpm for 15 minutes and formed a hazy dispersion with an oily film of test item visible at the surface.
Preliminary Volatility CheckA known amount of test item (1.0003 g) was weighed onto a watch glass and a steady stream of compressed air passed over the test item at a rate of 0.5 L/minute. The weight of test item remaining on the watch glass was determined every 10 minutes contact time for 70 minutes which showed a 38% and 64% loss of test item after 30 minutes and 70 minutes respectively.
Preliminary Analytical CheckAnalytical analysis confirmed that the test concentrations could not be maintained in the test preparations over an aeration period of 1 hour with values of 277, 137 and 94% of nominal at Time 0 for the test concentrations of 10, 100 and 1000 mg/L decreasing to values of 5 and 22% of nominal for the test concentrations of 10 and 1000 mg/L after 1 hour of aeration. No test item was measured after 1 hour in the test concentration of 100 mg/L (see Annex 4).It is unclear why values of 277% and 137% of nominal in the 10 and 100 mg/L test concentrations at 0 hours and then no test item was detected after 1 hours aeration in the 100 mg/L test vessel. Each weighing of the test item was correct and the results from the procedural recoveries indicate that the analytical method was appropriate.
As the test item concentrations could not be maintained after 1 hours aeration it will not be possible to conduct this study.The study was therefore cancelled.
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