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EC number: 204-101-2 | CAS number: 115-70-8
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given (comparable to guidelines/standards)
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Titration method
- GLP compliance:
- not specified
- Dissociating properties:
- yes
- pKa:
- 9.03
- Temp.:
- 25 °C
- Remarks on result:
- other: conc. 0.1 N
Reference
Data used in pKa calculations (AEPD-85, 0.384 g/250 mL):
mL 0.2000 N HCl |
pH |
temp. (°C) |
0.0 |
10.55 |
25.0 |
1.0 |
10.18 |
25.1 |
2.0 |
9.86 |
25.1 |
3.0 |
9.62 |
25.1 |
4.0 |
9.44 |
25.1 |
5.0 |
9.28 |
25.1 |
6.0 |
9.12 |
25.1 |
7.0 |
8.98 |
25.1 |
8.0 |
8.83 |
25.1 |
9.0 |
8.69 |
25.1 |
10.0 |
8.52 |
25.1 |
11.0 |
8.32 |
25.1 |
12.0 |
8.02 |
25.1 |
In addition, it is reported that a QSAR model has been developed for alkanoamines. The result for AEPD (9.08) confirms the experimental determination.
Description of key information
pKa = 9.03 at 25 °C
Key value for chemical safety assessment
Additional information
Titration method (no guideline named).
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