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EC number: 204-101-2
CAS number: 115-70-8
Based on the behaviour of the test item in algal medium and the impact
on the pH of the solution (increase), a second exposure was performed
using pH adjustments (pH 8.0 ± 0.1) of the exposure solutions. The
second exposure (Definitive test 2) should be considered more robust
than those of the first exposure (Definitive test 1). The exposure
conditions provided during the second test are more conclusive to
optimal algal growth and it is clear that the pH shift impacted the
observed endpoints in the first exposure.
ErC50(72h) = 548 mg/L for Pseudokirchneriella subcapitata (OECD 201)NOEC(72h) = 31.3 mg/L
There is one study on algal toxicity available for 2-amino-2-ethyl-1,3-propanediol
(AEPD), which was used as key study for the assessment. The study
was conducted according to OECD guideline 201 and GLP (Hoffmann, 2011).
The test organism Pseudokirchneriella subcapitata was exposed to AEPD in
a static system for 72 hours, at the test concentrations 11, 24, 55,
150, 390 and 980 mg a.i./L. The test was performed with and without pH
adjustment, leading to growth rate based EC50 values of 548 mg/L and 225
mg/L, respectively. NOEC values were 31.3 mg/L and 26.8 mg/L, with and
without pH adjustment, respectively. Based on this data, pH had an
effect on algal growth, and the value obtained with pH adjustment should
be used for the assessment of toxicity.
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