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EC number: 205-232-8
CAS number: 136-23-2
Based on the absence of any histopathological changes in the available 17-weeks oral study with rats and the findings of the available, albeit poorly reported carcinogenicity study with mice, zinc bis(dibutyldithiocarbamate) (ZDBC) is considered to be non-carcinogenic.
Based on the evidence from the available
oral carcinogenicity study with mice and the 17 -week oral study with
rats, zinc bis(dibutyldithiocarbamate) (ZDBC) does not need to be
classified for carcinogenicity in accordance with EU Directive
67/548/EEC and EU
Classification, Labelling and Packaging of Substances and Mixtures (CLP)
Regulation (EC) No. 1272/2008.
One carcinogenicity study with mice,
although poorly reported, was available for assessment (Innes et al.,
1969). Maximal tolerated dose (which corresponded to 1000 mg/kg bw/day)
was administered orally to 18 male and 18 female mice of 2 different
strains starting at the age of 7 days by oral gavage for the first 3
weeks and then in diet (corresponding to concentration in diet of 2600
ppm) for the rest of the study period of 18 months. After this the
animals were necropsied and histological evaluation of major organs and
all grossly visible lesions was performed. The paper reported an
overview of the results on selected pesticides and industrial compounds,
amounting in total to 120 substances. Only data on 11 compounds which
induced significant increase in tumor incidences were reported. No data
on tumor incidences are reported for zinc bis(dibutyldithiocarbamate),
as it gave no significant indication of tumorigenicity according to
In addition, the available 17-weeks study
with rats administered zinc bis(dibutyldithiocarbamate) (ZDBC) in diet
at levels up to 2500 ppm gave no indication of histopathological
changes, including hyperplasia or (pre)-neoplastic lesions. Based on the
overall evidence from these two studies, zinc
bis(dibutyldithiocarbamate) is considered to be not carcinogenic.
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