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EC number: 205-232-8
CAS number: 136-23-2
Acute toxicity of zinc bis(dibutyldithiocarbamate) (ZDBC) by oral and dermal exposure routes is low. Several acute oral toxicity studies give oral LD50 value over 5000 mg/kg bw for rats, while two acute dermal toxicity studies with rabbits give LD50 > 2000 mg/kg bw/day. No data on acute inhalation toxicity were available; however, in accordance with REACH Annex VIII, the study does not need to be conducted, as data on two other routes of exposure are available.
Four acute oral toxicity studies with zinc
bis(dibutyldithiocarbamate) (ZDBC) were available for assessment, all
reporting LD50 values well above 2000 mg/kg bw. Out of these studies,
the most recent one (Monsanto Company, 1982a), performed under GLP, was
chosen as a key study. Five Sprague-Dawley rats of each sex were
administered a single oral dose of 5000 mg/kg bw of the test substance
as a 434 mg/ml suspension in corn oil. No mortalities occurred and no
abnormal findings were noted at necropsy. Diarrhoea occurred in three
males and five female rats on the day of dosing, but this effect was
probably induced by the corn oil used as the dosing vehicle.
Two acute dermal toxicity studies with
rabbits were available for assessment, one with very limited reporting.
Respectively, the other one, more recent GLP-compliant study (Monsanto
Company, 1982b) was chosen as a key study. The test material moistured
with physiological saline was administered to abraded skin of a dorsal
surface of five New Zealand White rabbits of each sex in the amount of
2000 mg/kg bw under occlusive conditions. After 24 hours the patch was
removed, the excessive test material wiped off, and the animals were
observed for 14 days and necropsied afterwards. There were no
mortalities. Erytherna was observed in the exposed area of three male
animals and one female rabbit on the first day after exposure. No other
clinical abnormalities were noted. At necropsy, pale renal coloration
was observed in one male animal, but this was not considered to be
related to exposure to the test material. No abnormalities were observed
in the remaining nine rabbits.
No data on acute inhalation toxicity of zinc
bis(dibutyldithiocarbamate) were available. However, in accordance with
REACH Annex VIII, the study does not need to be conducted, as the data
on two other routes of exposure are available.
Based on the acute oral LD50 of > 5000 mg/kg
and the acute dermal LD50 of > 2000 mg/kg, ZDBC should not be classified
as hazardous to health after acute exposure, according to the EU
Directive 67/548/EEC and EU
Classification, Labelling and Packaging of Substances and Mixtures (CLP)
Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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