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EC number: 204-815-4
CAS number: 126-97-6
a study carried out according to OECD Test Guideline 412, groups of 5
male and 5 female Wistar rats were exposed nose-only to 2-aminoethanol
aerosol (with a vapour fraction; purity of the test substance: 99.93%)
for 28 days, for 6 hours a day, on 5 days a week. The test
concentrations were 0, 10, 50 or 150 mg/m³ (analysed concentrations:
10.2, 49.1 and 155.9 mg/m³;
MMAD = 1.1 to 1.2 μm, with about 70% of the particles below 3 μm; the
aerosol fraction was 0.5, 26.4 and 134.5 and the vapour fraction was
9.8, 22.7 and 21.4 mg/m³).
on the larynx, trachea and lungs were found at 150 mg/m³
above. There were no adverse systemic effects. The MCHC (mean
corpuscular haemoglobin concentration) was increased in male rats at 50
above. As this increase was not accompanied by any other changes in red
blood cell parameters, the effect was regarded as substance-related, but
not as adverse. In addition, at 150 mg/m³,
the triglyceride values of the males were reduced. This effect was not
regarded as adverse because no concomitant findings were observed. The
relative liver weights of all treated males were significantly
decreased, but the decrease was not concentration-dependent. This
finding was not regarded as substance-related because there was no
concentration–effect relationship or histopathological correlate.
or slight focal or multifocal hyperplasia of mucous cells was found in
the bronchi of the lungs of all male rats and of 2 female rats of the
group exposed to 150 mg/m³.
The number of goblet cells was minimally or slightly increased in the
to slight inflammation of the trachea was observed in 1 male after
exposure to 10 mg/m³as well as in 4 males after exposure to 150 mg/m³.
In addition, at the high concentration, minimal or slight focal squamous
metaplasia was observed in the area of the carina in males. There were
no treatment-related findings in the trachea of the females. However, 1
female control animal was found to have minimal focal inflammation of
the trachea. The inflammation of the trachea observed in 1 male exposed
to 10 mg/m³was not concentration-dependent; therefore, it was not
induced by the substance.
the entrance to the ventral pouch of the larynx (plane of section III),
minimal (grade 1) focal squamous metaplasia was observed in 1 female at
well as in 1 male and 2 females at 150 mg/m³. Minimal hyperplasia
occurred in all males and in 4 females (concentration not specified).
Minimal inflammation was found in 2 males and 3 females at 50 mg/m³as
well as in all males and 4 females at 150 mg/m³.
the base of the epiglottis in the larynx (plane of section I),
submucosal inflammation characterized by infiltrates of granulocytes
and lymphoid cells occurred in all males and females at 50 mg/m³and
above. At 150 mg/m³, the inflammation was accompanied by degeneration of
the submucosal glands. In addition, focal epithelial necrosis was
observed at the base of the epiglottis in 4 males and 3 females of the
high concentration group. In the same region, focal squamous cell
metaplasia was observed in 3 male and 2 female rats at 50 mg/m³,
and all animals were affected at 150 mg/m³. Minimal inflammation at the
base of the epiglottis was detected in 1 female exposed to 10 mg/m³
resulting local NOAEC for rats after 28-day exposure was 10 mg/m³, and
the systemic NOAEC was 150 mg/m³.
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