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EC number: 204-815-4
CAS number: 126-97-6
21-Day NOEC = 5.3 mg/L (OECD TG 211, Daphnia magna, RL2, GLP; read-across from TGA, molecular weight correction)
No experimental data on long-term toxicity to aquatic invertebrates is available for the target substance MeaTG. However, a study was conducted with teh source substance TGA. A category justification is attached to Iuclid section 13.
A Daphnia magna reproduction test was conducted according to OECD Guideline 211 (Draft, April 1997). Daphnids, aged less 24 hours at the start of the test, were exposed to thioglycolic acid at nominal concentrations of 0.0 (control), 5.4, 8.6, 13.7, 21.9, and 35.0 mg/L; corresponding to measured concentrations of 0.0, 1.2, 1.7, 2.7, 6.5, and 24.2 mg/L) for 21 days under semi-static conditions (daily renewal). At the end of the test, the total number of living offspring produced was assessed. Because the measured concentrations were outside of ± 20% of the nominal concentrations, the time-weighted average of the measured concentration was used to calculate the test results.
The mortality rate of the parent Daphnia magna in the control was 10% at the end of exposure, meeting the test acceptance criteria of 20% or less.
In the concentrations, as the test substance concentration increased, the number of deaths and mortality rate of parent Daphnia magna increased at the end of exposure, and in the concentration of 1.7 mg/L, the mortality rate of parent Daphnia magna was 30%, and it was 100% in the maximum concentration (24.2 mg/L)
The first hatching date for the parent Daphnia magna in the control was 10 to 11 days after the start of exposure. In the concentration of 1.7 mg/L, the first hatching date for the parent Daphnia magna was 10 to 14 days after the start of exposure, and in the highest concentration (24.2 mg/L), no offspring of the parent Daphnia magna was found.
The mean cumulative number of litter per parent Daphnia magna during the 21-day control zone was 67.8, meeting the test acceptance criteria of 60 or more.
The mean cumulative number of offspring per parent Daphnia magna during the 21-day concentrations was 74.4 animals in the lowest concentration (1.7 mg/L), and all of the parent Daphnia magna died in the highest concentration (24.2 mg/L) at 21 days of exposure.
No dormant eggs, etc. occurred in the control or any of the concentration.
21-Day No Observed Effect Concentration (NOECr) = 2.7 mg/L
21-Day Lowest Observed Effect Concentration (LOECr) = 6.5 mg/L
21-Day 50% Lethal Concentration of Parent Daphnia magna (LC50) = 5.7 mg/L (95% confidence interval: 3.4 mg/L - 11.2 mg/L)
21-Day 50% Reproductive Inhibition Concentration (ErC50) = 4.1 mg/L (95% confidence interval: 3.6 mg/L - 4.8 mg/L)
After molecular weight correction, the 21 d NOEC for MeaTG is 5.3 mg/L, and the LOEC is 12.7 mg/L.
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