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EC number: 204-815-4
CAS number: 126-97-6
The study was performed in compliance with its quality criteria:- Test daphnids in the control were not trapped at the surface of the water.- Concentration of dissolved oxygen in the test vessel remained above 2 mg/L at end of the test and pH did not vary by more than 1 unit.- No more than 10 % of the daphnids immobilized in the control at the end of the test.- Concentrations of the test substance were maintained to within 80 % of the initial concentrations throughout the duration of the test.
A study was performed to assess the acute toxicity of the test material to Daphnia magna. The method followed that described in the OECD Guidelines for Testing of Chemicals (April 2004) No 202, "Daphnia sp, Acute Immobilisation Test" referenced as Method C.2 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC).Following a preliminary range-finding test, twenty daphnids (2 replicates of 10 animals) were exposed to an aqueous solution of the test material at concentrations of 10, 18, 32, 56 and 100 mg active ingredient (ai)/l for 48 hours at a temperature of approximately 20°C under dynamic test conditions. The number of immobilised Daphnia were recorded after 24 and 48 hours.A positive control conducted approximately every six months used potassium dichromate as the reference material. The 48-Hour ECso for the test material to Daphnia magna based on nominal test concentrations was 49 mg ai/l with 95% confidence limits of 41 - 61 mg ai/l. The No Observed Effect Concentration was 18 mg ai/l.Given that the relevant test concentrations (18, 32, 56 and 100 mg ai/l) of the test material MEATG were within the 80% to 120% acceptance limits, it was considered justifiable to base the results on nominal test concentrations only.The 48-Hour EC50 for the reference material to Daphnia magna based on nominal concentrations was 0.75 mg/l with 95% confidence limits of 0.56 — 1.0 mg/l.
48 h EC50 = 63.53 mg/L (Daphnia magna, OECD TG 202; geom. mean TGA, MeaTG)
Experimental data on short-term toxicity to aquatic invertebrates are available for TGA and MeaTG.
Two reliable studies on short-term toxicity of Thioglycolic acid to Daphnia magna are available.
The acute toxicity (inhibition of mobility) of Thioglycolic acid for Daphnia magna was assessed according to OECD Guideline 202.
Daphnia magna (10/concentration) were exposed for 48 hours to an aqueous solution of thioglycolic acid at different nominal concentrations of 0.20 - 0.39 - 0.78 - 1.56 - 3.13 - 6.25 - 12.5 - 25 and 50 mg/L.
15% immobilisation of the test organisms was recorded after 24h of exposure at the highest test concentration of 47 mg/L.
The 48 h EC 50 was determined to be 38 mg/L, based on measured concentrations. Even though it is known that thioglycolic acid can be easily oxidized, the conditions of the test surely prevented such kind of chemical action (lack of catalysts, buffer, pH, etc). This explained the stability of the concentrations tested throughout the test even in static conditions.
Immobilisation in the control did not exceed 10 % at the end of the test. Concentration of dissolved oxygen in the test vessels remained above 2 mg/L at the end of the test and pH did not vary by more than 1 unit. The concentrations of the test substance have been maintained to within 80 % of the initial concentration throughout the duration of the test.
The acute toxicity of Thioglycolic acid to Daphnia magna has been investigated in a test in accordance with OECD Guideline 202 (1984) under semi-static conditions. The Daphnia were exposed to test chemical at nominal concentrations of 4.8 mg/L, 8.6 mg/L, 15.4 mg/L, 27.8 mg/L, 50.0 mg/L, 90.0 mg/L (Measured concentrations control (0.0), <0.2 mg/L, 1.1 mg/L, 1.6 mg/L, 17.2 mg/L, 41.0 mg/L, 84.6 mg/L).
The tested substance concentration in the test solution was measured at the start of exposure and 24 hours later. The test substance concentration at the start of the test was 0.5 to 85.3 mg/L (the set concentration was 4.8 to 90.0 mg/L), and the proportion relative to the set concentration was 10.4 to 94.8%. The test substance concentration at the 24 hours after the start of the test was < 0.1 to 84.0 mg/L (the set concentration was 4.8 to 90.0 mg/L), and the proportion relative to the set concentration was < 1.3 to 93.3%. Because the measured value was outside of ± 20% of the set concentration, the geometric mean of the measured concentration was used to calculate the test results.
EC 50 - 48h for immobilisation determined was 35.8 mg/L.
Supporting data are available for the oxidation product Diammonium dithioglycolate. Diammonium dithioglycolate is the main degradation product of thioglycolic acid when released in the environment occuring few hours after the release (Devaux, 2003 - Smolin and Fölsing, 2009).
Acute toxicity of Diammonium dithioglycolate to Daphnia magna has been investigated through a test in accordance with OECD Guideline 202 and GLP requirements.
Daphnia magna were exposed for 48 hours to an aqueous solution of Diammonium Dithiodiglycolate at a nominal concentration of 100 mg/L.
The 48 h EC 50 was determined to be >100 mg/L.
Overall, all three results are combined in a geometric mean value after adjustment to thioglycolate.The Overall 48 h EC50 for MeaTG is 63.53 mg/L
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