Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-815-4
CAS number: 126-97-6
No pH dependence of the results was detectable.
The majority of the applied 14C was removed from the skin by rinsing after the actual exposure and after the neutralization
step (means of 96.1 to 96.8 % of the
The mean 14C-content of the skin at the site of application was 0.82 %, 0.57 % and 0.60 % (study
A, B and C, respectively) of the administered 14C-amount.
Means of 0.139 %, 0.119 % and 0.137 % of the applied 14C were recovered in urine and faeces within 72 hours.
excreted to a larger extent via urine (means 79 %, 76 % and 80 % of the eliminated amounts). The mean excretion was fast:
92 %, 83 % and 93 % of the totally eliminated amounts were excreted in the first 24 hours after application.
The remaining mean amounts of 14C in the carcass 3 days after the application were 0.126 %, 0.116 % and 0.121 % of the
administered 14C-amount. This corresponds to 46.7 %, 48.3 % and 46.5 % of the absorbed 14C-amount.
The red foci that appeared in the application site of several animals of all pH groups did not have a distinct influence on the
In the three studies the cutaneous absorption as well as the 14C-concentration found in urine, faeces and carcass were
higher in males than in females without gaining statistical
Means of 97 % to 97.9 % of the applied 14C-doses were recovered in the
various types of samples in the three studies.
From these results the mean absorption was calculated to be 0.27 %, 0.24 % and 0.26 % of the applied dose.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again