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EC number: 204-815-4 | CAS number: 126-97-6
No pH dependence of the results was detectable. The majority of the applied 14C was removed from the skin by rinsing after the actual exposure and after the neutralization
step (means of 96.1 to 96.8 % of the applied dose). The mean 14C-content of the skin at the site of application was 0.82 %, 0.57 % and 0.60 % (study A, B and C, respectively) of the administered 14C-amount. Means of 0.139 %, 0.119 % and 0.137 % of the applied 14C were recovered in urine and faeces within 72 hours. 14C was
excreted to a larger extent via urine (means 79 %, 76 % and 80 % of the eliminated amounts). The mean excretion was fast:
92 %, 83 % and 93 % of the totally eliminated amounts were excreted in the first 24 hours after application. The remaining mean amounts of 14C in the carcass 3 days after the application were 0.126 %, 0.116 % and 0.121 % of the
administered 14C-amount. This corresponds to 46.7 %, 48.3 % and 46.5 % of the absorbed 14C-amount. The red foci that appeared in the application site of several animals of all pH groups did not have a distinct influence on the
absorption. In the three studies the cutaneous absorption as well as the 14C-concentration found in urine, faeces and carcass were
higher in males than in females without gaining statistical significance. Means of 97 % to 97.9 % of the applied 14C-doses were recovered in the various types of samples in the three studies. From these results the mean absorption was calculated to be 0.27 %, 0.24 % and 0.26 % of the applied dose.
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