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EC number: 218-485-4
CAS number: 2162-73-4
A study on the acute oral
toxicity of 2,4-Triisopropylbenzoldiisocyanat for male and
female Wistar rats (Bomhard, 1990) was conducted according
to the OECD Guideline 401 - standard acute method with the
only deviation that the acclimatisation period was only 4
days. This deviation is not judged to influence the
results of the study significantly. A dose of 2000 mg/kg
bw of the test substance was administered via gavage to
the rats. Observations were made for a period of 14 days.
No treatment-related mortalities or signs of systemic
toxicity, beside piloerection during the first 24 hours
following administration and an increased urine production
on the following day, were observed.
One female rat died 3 hours
after application, as clinical signs hypersalivation and
laboured breathing were noted.
No treatment-related body
weight changes were reported.
In the one female rat
pathological abnormalities (hyperaemic lung and stomach)
were found, in all other animals sacrificed at the end of
the observation period no pathological findings were
noted. The acute oral median lethal dose (LD50) of the
test material in rats of both sexes observed over a period
of 14 days was estimated to be greater than 2000 mg/kg bw.
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